Jimson Weed - Uses and Side Effects

The ripe seeds and flowers without leaves are also used. Seeds are small, long, flat, and dark yellow to brown. Jimson weed's primary action isanticholinergic, caused by 0.1 % to 0.6% atropine, hyoscyamine, and scopolamine. All parts of the plant contain these compounds, but the highest concentration is in the seeds. Anticholinergic levels in other plant parts vary from year to year and from plant to plant. The alkaloids are readily absorbed across GI mucous membranes and across the respiratory tract. Anticholinergic effects usually occur within 60 minutes and may last 24 to 48 hours because of impaired GI motility.Safety Risk Jimson weed is listed as an unsafe herb by FDA. It isn't recommended for routine therapeutic use.Reported usesJimson weed is used to treat asthma and cough from bronchitis or influenza, usually by smoking cigarettes made from the leaves. It's also used to treat disorders of the autonomic nervous system. Little data exist to support routine therapeutic use of jimson weed.Illicitly, the seeds have been chewed, the leaves smoked as cigarettes, and a tea brewed and ingested to cause hallucinations and euphoria.AdministrationDosage and administration aren't well documented.HazardsAdverse reactions to jimson weed include headache, confusion, hallucinations, agitation, emotional lability, motor incoordination, restlessness, loss of consciousness, hyperthermia, tachycardia, dilated pupils, blurred vision, photophobia, dry mucous membranes, nausea, vomiting, decreased GI tract motility, dry mouth, urinary retention, tachypnea, dry, flushed skin, and hypertension leading to hypotension.Additive effects may be seen with anticholinergics such as benzotropine, atropine, scopolamine; with antihistamines such as diphenhydramine; with phenothiazines such as prochlorperazine and promethazine; and with tricyclic antidepressants such as amitriptyline and imipramine. Use of jimson weed with deadly nightshade (belladonna) may cause additive anticholinergic toxicity.Patients who are pregnant or breast-feeding should avoid use. Those with glaucoma, benign prostatic hyperplasia, urinary retention, tachycardia, or hypersensitivity to jimson weed
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